The Company
Founded in 2014, Varocto Inc. is an ophthalmic research and development company located in the City of Orange, California. Varocto is a spin-off of Alfred E. Mann Institute at USC. We are developing the next generation non-invasive retinal vascular screening machine utilizing OCT (Optical Coherence Tomography) and OCTA (Optical Coherence Tomographic Angiography). OCT angiography is a non-invasive new technology to image the three dimensional vasculature of the eye without requiring pupil dilation and without any injection of dye. For many eye diseases including diabetes and age-related macular degeneration, non-invasive screening for the occurrence of retinal vascular problems before vision has been damaged has the potential to improve overall eye health.
Images
This gallery of images was produced from data acquired from multiple development machines and processed using our proprietary OCT angiography algorithm. Images courtesy of Varocto, California Institute of Technology, University of Southern California, and University of California Davis.

What is OCT?
Optical coherence tomography (OCT) is an imaging technology which uses light to non-invasively image the three-dimensional structure of the retina.
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Optical coherence tomography (OCT) is an imaging technology which uses light to non-invasively image the three-dimensional structure of the retina. It is a commonly used tool by ophthalmologists to identify structural abnormalities in diseased eyes. |

What is OCT angiography?
Non-invasive vascular screening such as OCT angiography holds the potential to enhance overall eye health through retinal vascular screening.
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OCT Angiography is a new direction in retinal screening technologies, providing a non-invasive method to image the three dimensional structure of the retinal and choroidal vasculature. Developed as an additional functionality to optical coherence tomography (OCT), which produces three dimensional structural images, OCT angiography visualizes regions of fluctuating signal based on the blood flow present in vessels. The three dimensional vascular data can be presented in multiple ways, including as a two-dimensional color map vascular image where the color represents the depth location of the vasculature.

Non-invasive vascular screening such as OCT angiography holds the potential to enhance overall eye health through retinal vascular screening, for diseases such as diabetic retinopathy and age-related macular degeneration. OCT angiography is a functional addition to OCT, which allows for non-invasive imaging of the three dimensional vasculature of the retina and choroid.
The three dimensional vascular data can be presented in multiple ways, including as a two-dimensional color map vascular image where the color represents the depth location of the vasculature.
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A range of possibilities
OCT Angiography can be tailored to view different types of vascular features, from the largest vessels in the eye all the way down to the smallest microvasculature.
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OCT angiography can be tailored to view different types of vascular features, from the largest vessels in the eye all the way down to the smallest microvasculature. Large field of view scans can help observe major vessels of the eye, and zooming in on specific regions of interest can view microvascular features.
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A non-invasive alternative
Fluorescein angiography (FA) is the most common form of retinal vascular imaging, which typically requires an injection of dye to be able to view flow.
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Comparison of the fovea region of a subject with diabetic retinopathy with fluorescein angiography (FA, left) and our method of OCT angiography (right). |
A regional comparison of a diabetic retinopathy subject imaged with FA (left) and our method of OCT angiography (right) highlights very similar structure. Regions where there no longer exists any microvasculature are outlined in red on the OCT angiographic image. |
Fluorescein angiography (FA) is the most common form of retinal vascular imaging, which typically requires an injection of dye to be able to view flow. OCT angiography holds the potential of being used as a non-invasive alternative to this technology. |
Images courtesy of Varocto, California Institute of Technology, University of Southern California, and University of California Davis |